Introduction

Katherine Eban's journey into the world of generic drugs began with a simple phone call from Joe Graedon, host of NPR's The People's Pharmacy. Patients were reporting serious problems with their generic medications - drugs that were supposed to be equivalent to brand-name versions but somehow weren't working right. Some patients who had been stable on brand-name medications for years suddenly relapsed when switched to generics. Others experienced devastating side effects. The Food and Drug Administration (FDA) maintained everything was fine, but the mounting evidence suggested otherwise.

This mystery launched Eban on a decade-long investigation that took her across four continents, deep into pharmaceutical manufacturing plants, and face-to-face with whistleblowers who risked everything to expose the truth. In China, government officials followed her and hacked her phone. In Mexico, a source passed her stacks of internal documents in a bar. In India, she uncovered widespread fraud in drug testing and manufacturing.

The reality she discovered was sobering. While generic drugs have made life-saving medications affordable for millions worldwide, the push for ever-lower prices has created dangerous compromises in quality. Many generic drugs are manufactured in facilities that cut corners, falsify data, and deceive regulators. The book's findings are particularly relevant because generic drugs now make up 90% of America's drug supply. Yet as Eban discovered, current regulatory systems aren't equipped to ensure consistent quality across this vast global manufacturing network. Her work exposes not just individual bad actors, but systemic problems in how generic drugs are made, tested, and regulated.


Join us, as we take an unprecedented look behind the scenes of an industry that affects nearly everyone who takes medication.

Summary

The fight for drug quality remains unresolved. While Ranbaxy crumbled and whistleblowers like Dinesh Thakur spoke out, the FDA gradually softened its stance on inspections. Peter Baker's discoveries in China and India exposed widespread fraud, but regulatory compromises persisted. Even today, the same forces that prioritized profits over safety continue to shape our medicine supply, leaving patients to bear the invisible costs.

When Medicine Meets Morality

In late 2001, while autumn leaves turned gold and crimson in Hopewell, New Jersey, Dinesh Thakur, a 33-year-old information scientist at Bristol-Myers Squibb (BMS), met his senior colleague Rashmi Barbhaiya for what seemed like a casual walk. BMS's campus embodied everything about structured, regulated American pharmaceutical manufacturing - from its precisely mowed grass to the carefully placed emergency poles every hundred feet. This was where groundbreaking drugs like Pravachol and Plavix were developed, where scientists won prestigious awards, and where...